反应详情

温度

82.5 °C

5-(-2-aminopropyl]-2-methoxybenzenesulfonamide (200 g) was dissolved in dimethylformamide (950 ml) and 1-(2-Bromoethoxy)-2-ethoxybenzene (100.3 g) was added. The reaction mixture was heated to 80-85° C. for 4 hours. Dimethylformamide was then distilled off under vacuum. Water (1000 ml) was added to solid residue and the mixture was heated to 80-90° C. under stirring for 2 hours. The mixture was cooled to room temperature. Formed crystals were filtered off and were suspended in water (900 ml). Suspension was heated to 80-90° C. under stirring for 2 hours. Crystals were filtered, washed with water (200 ml) and dried to give tamsulosin base (150 g, 89.8%).

1. distillationDimethylformamide was then distilled off under vacuum
2. additionWater (1000 ml) was added to solid residue
3. temperaturethe mixture was heated to 80-90° C.
4. temperatureThe mixture was cooled to room temperature
5. customFormed crystals
6. filtrationwere filtered off
7. temperatureSuspension was heated to 80-90° C.
8. stirringunder stirring for 2 hours
9. filtrationCrystals were filtered
10. washwashed with water (200 ml)
11. customdried