HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbamate → HCID 22283296, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbamate | HCID 276 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Reactant | HCID 22283106 | HCID 22283106 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | HCID 22283296 | HCID 22283296 | 72% |
Reaction Steps
Conversion of 4-cloromethyl-N-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-benzamide (84 mg, 0.20 mmol) with 1-BOC-piperazine (372 mg, 1.9 mmol) using the general procedure C and afterwards cleavage of the neat carbamate in trifluoroacetic acid (1 ml) followed by saturated aqueous sodium carbonate affords the product as colorless crystals in 72% yield. MS: m/e=468 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06835732B2 |
| Source dataset | uspto-grants-2004_12 |
| ORD ID | ord-9f9e2d4f45a84bb09e2a525d6ceec792 |
| Source note | uspto-grants-2004_12 |