Phosgene → HCID 86584923, compound

HRID 2308478Notes

Reaction equation

HRID 2308478 reaction equation
[NH2:1][C:2]1[S:3][C:4]2[C:10]([N:11]3[CH2:16][CH2:15][O:14][CH2:13][CH2:12]3)=[CH:9][CH:8]=[C:7]([O:17][CH3:18])[C:5]=2[N:6]=1.[C:19](Cl)(Cl)=[O:20].[NH:23]1[CH2:28][CH2:27][O:26][CH2:25][CH2:24]1>>[CH3:18][O:17][C:7]1[C:5]2[N:6]=[C:2]([NH:1][C:19]([N:23]3[CH2:28][CH2:27][O:26][CH2:25][CH2:24]3)=[O:20])[S:3][C:4]=2[C:10]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)=[CH:9][CH:8]=1

Participants

4

Reactant 3

HCID 6371PhosgeneHCID 8083MorpholineHCID 114028614-Methoxy-7-morpholinobenzo[d]thiazol-2-amine

Product 1

HCID 86584923HCID 86584923, compoundYield 25%

Procedure

Conversion of 2-amino-4-methoxy-7-morpholin-4-yl-benzothiazol (100 mg, 0.377 mg) with phosgene (20% in toluene, 0.2 ml) and morpholine (0.041 ml, 0.47 mmol) using the general procedure D affords the product as white solid in 25% yield. MS: m/e=379 (M+H+).

Sources & evidence

ORD record
ord-d023a9b69f1f4a7396c7952e8373baee
Source dataset
uspto-grants-2004_12
Patent number
US06835732B2

Reaction notes

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