HCID 22283409, compound → HCID 22283382, compound

HRID 2308491Notes

Reaction equation

HRID 2308491 reaction equation
[F:1][C:2]1[CH:23]=[CH:22][C:5]([C:6]([NH:8][C:9]2[S:10][C:11]3[C:17]([CH:18]=[CH2:19])=[CH:16][CH:15]=[C:14]([O:20][CH3:21])[C:12]=3[N:13]=2)=[O:7])=[CH:4][CH:3]=1>CO.[Pd]>[CH2:18]([C:17]1[C:11]2[S:10][C:9]([NH:8][C:6](=[O:7])[C:5]3[CH:22]=[CH:23][C:2]([F:1])=[CH:3][CH:4]=3)=[N:13][C:12]=2[C:14]([O:20][CH3:21])=[CH:15][CH:16]=1)[CH3:19]

Participants

4

Reactant 1

HCID 22283409HCID 22283409, compound

Product 1

HCID 22283382HCID 22283382, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

100 mg of 4-fluoro-N-(4-methoxy-7-vinyl-benzothiazol-2-yl)-benzamide (0.3 mmol) were dissolved in methanol (100 ml) and Pd/C (4 mg) were added. The reaction mixture was hydrogenated for 2 hrs. After filtering and evaporation of the solvent the crude product was subjected to column chromatography (silica gel, eluent MeOH/CH2Cl2 1:9). The title compound was obtained in form of white crystals (79%); F.p.: 165-167° C.

Workup

  1. filtrationAfter filtering
  2. customevaporation of the solvent the crude product

Sources & evidence

ORD record
ord-dc15d3f3e3864b6daacd42cc2ec90a18
Source dataset
uspto-grants-2004_12
Patent number
US06835732B2

Reaction notes

Loading…