Formic Acid → HCID 86584944, compound

HRID 2308514Notes

Reaction equation

HRID 2308514 reaction equation
[CH3:1][O:2][C:3]1[C:8]2[N:9]=[C:10]([NH:12][C:13]([C:15]3[S:16][C:17]([CH3:20])=[CH:18][CH:19]=3)=[O:14])[S:11][C:7]=2[C:6]([N:21]2[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]2)=[CH:5][CH:4]=1.[CH:27](O)=O.C=O>CO>[CH3:1][O:2][C:3]1[C:8]2[N:9]=[C:10]([NH:12][C:13]([C:15]3[S:16][C:17]([CH3:20])=[CH:18][CH:19]=3)=[O:14])[S:11][C:7]=2[C:6]([N:21]2[CH2:22][CH2:23][N:24]([CH3:27])[CH2:25][CH2:26]2)=[CH:5][CH:4]=1

Participants

5

Reactant 3

HCID 284Formic AcidHCID 712FormaldehydeHCID 865849425-Methyl-thiophene-2-carboxylic acid (4-methoxy-7-piperazin-1-yl-benzothiazol-2-yl)-amide

Product 1

HCID 86584944HCID 86584944, compoundYield 34%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 5-methyl-thiophene-2-carboxylic acid (4-methoxy-7-piperazin-1-yl-benzothiazol-2-yl)-amide (100 mg, 0.26 mmol) in methanol (8 ml) were added formic acid (100 μl, 2.6 mmol) and formaldehyde (23 μl, 0.31 mmol) and the mixture refluxed for 18 h. Workup and purification as described for 5-methyl-thiophene-2-carboxylic acid (4-methoxy-7-piperazin-1-yl-benzothiazol-2-yl)-amide afforded the product as light yellow powder (34%), MS: m/e=403(M+H+).

Workup

  1. temperaturethe mixture refluxed for 18 h
  2. customWorkup and purification

Sources & evidence

ORD record
ord-8dd9e8c0dee2472f929fa1b3ed6c9228
Source dataset
uspto-grants-2004_12
Patent number
US06835732B2

Reaction notes

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