Morpholine → 4-(4-Benzyloxy-3-nitro-phenyl)-morpholine

HRID 2308516Notes

Reaction equation

HRID 2308516 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[CH2:7]([O:14][C:15]1[CH:20]=[CH:19][C:18](Br)=[CH:17][C:16]=1[N+:22]([O-:24])=[O:23])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.COC1C=CC(N2CCOCC2)=CC=1[N+]([O-])=O>>[CH2:7]([O:14][C:15]1[CH:20]=[CH:19][C:18]([N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)=[CH:17][C:16]=1[N+:22]([O-:24])=[O:23])[C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1

Participants

4

Reactant 3

HCID 8083MorpholineHCID 112782421-(Benzyloxy)-4-bromo-2-nitrobenzeneHCID 177470104-(4-Methoxy-3-nitrophenyl)morpholine

Product 1

HCID 222833454-(4-Benzyloxy-3-nitro-phenyl)-morpholine

Procedure

The title compound was prepared using morpholine and 1-benzyloxy-4-bromo-2-nitro-benzene (prepared from 4-bromo-2-nitro-anisol and benzyl bromide) using the general method of example “4-(4-methoxy-3-nitro-phenyl)-morpholine” as yellow solid (58%), MS: m/e=315(M+H+).

Sources & evidence

ORD record
ord-055d163dad4844af8496feba2f4cc17b
Source dataset
uspto-grants-2004_12
Patent number
US06835732B2

Reaction notes

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