1-Acetylpiperidine-4-carbonyl chloride → 1-Acetyl-piperidine-4-carboxylic acid (4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amide

HRID 2308522Notes

Reaction equation

HRID 2308522 reaction equation
[NH2:1][C:2]1[S:3][C:4]2[C:10]([N:11]3[CH2:16][CH2:15][O:14][CH2:13][CH2:12]3)=[CH:9][CH:8]=[C:7]([O:17][CH3:18])[C:5]=2[N:6]=1.[C:19]([N:22]1[CH2:27][CH2:26][CH:25]([C:28](Cl)=[O:29])[CH2:24][CH2:23]1)(=[O:21])[CH3:20]>>[CH3:18][O:17][C:7]1[C:5]2[N:6]=[C:2]([NH:1][C:28]([CH:25]3[CH2:24][CH2:23][N:22]([C:19](=[O:21])[CH3:20])[CH2:27][CH2:26]3)=[O:29])[S:3][C:4]=2[C:10]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)=[CH:9][CH:8]=1

Participants

3

Reactant 2

HCID 1009501-Acetylpiperidine-4-carbonyl chlorideHCID 114028614-Methoxy-7-morpholinobenzo[d]thiazol-2-amine

Product 1

HCID 101803031-Acetyl-piperidine-4-carboxylic acid (4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amide

Procedure

Using 2-amino-4-methoxy-7-morpholin-4-yl-benzothiazol and 1-acetyl-piperidine-4-carbonyl chloride the title compound was obtained as a white solid (22%), MS: m/e=419(M+H+).

Sources & evidence

ORD record
ord-cedf5f51ebb845cc91dd6aff613f575e
Source dataset
uspto-grants-2004_12
Patent number
US06835732B2

Reaction notes

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