Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 2-Methoxyethyl chloroformate | HCID 69400 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 4-Methoxy-7-morpholinobenzo[d]thiazol-2-amine | HCID 11402861 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 11280081 | HCID 11280081 | — |
Reaction Steps
4-Methoxy-7-morpholin-4-yl-benzothiazol-2-yl-amine (300 mg, 1.1 mmol) and N-ethyldiisopropylamine (0.56 ml, 3.4 mmol) were dissolved in tetrahydrofurane (11 ml) and 2-methoxyethyl chloroformate (0.19 ml, 1.4 mmol) were added over 5 min. Then the mixture was heated to 70° C. for 3 h. The mixture was cooled to room temperature, water added and extracted twice with ethyl acetate. The combined organic phases were dryed with Na2SO4 and evapprated to dryness. The title compound was obtained as off-white solid (52%). MS: m/e=368 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06835732B2 |
|---|
| Source dataset | uspto-grants-2004_12 |
|---|
| ORD ID | ord-41d8d68d3a1d4e3896f45e4cf30f8c1d |
|---|
| Source note | uspto-grants-2004_12 |
|---|
