HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrrolidine → 4-Fluoro-N-(4-methoxy-7-pyrrolidin-1-yl-benzothiazol-2-yl)-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 4-Bromo-2-nitroanisole | HCID 118533 | — |
| Reactant | 4-fluoro-N-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-benzamide | HCID 10200214 | — |
| Product | 4-Fluoro-N-(4-methoxy-7-pyrrolidin-1-yl-benzothiazol-2-yl)-benzamide | HCID 22283185 | — |
Reaction Steps
The title compound was prepared strarting from 4-bromo-1-methoxy-2-nitro-benzene and pyrrolidine as described for 4-fluoro-N-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-benzamide (Example 275) and obtained as a light brown solid in about 10% overall yield, MS: m/e=372 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06835732B2 |
| Source dataset | uspto-grants-2004_12 |
| ORD ID | ord-6554cc33d2b14be7809b881419c31f8d |
| Source note | uspto-grants-2004_12 |