Sodium Hydroxide → HCID 57763209, compound

HRID 230854Notes

Reaction equation

HRID 230854 reaction equation
[NH2:1][C:2]([C:4]1[CH:5]=[N:6][C:7]2[C:12]([C:13]=1[NH:14][C:15]1[CH:20]=[CH:19][C:18]([F:21])=[C:17]([O:22][CH3:23])[CH:16]=1)=[CH:11][C:10]([S:24][CH2:25][CH2:26][C:27]([O:29]CC)=[O:28])=[CH:9][C:8]=2[CH3:32])=[O:3].[OH-].[Na+]>C(O)C>[NH2:1][C:2]([C:4]1[CH:5]=[N:6][C:7]2[C:12]([C:13]=1[NH:14][C:15]1[CH:20]=[CH:19][C:18]([F:21])=[C:17]([O:22][CH3:23])[CH:16]=1)=[CH:11][C:10]([S:24][CH2:25][CH2:26][C:27]([OH:29])=[O:28])=[CH:9][C:8]=2[CH3:32])=[O:3]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 57763252HCID 57763252, compound

Product 1

HCID 57763209HCID 57763209, compoundYield 89.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of Intermediate 52 (0.95 g) in ethanol (10 ml) was treated with 2M sodium hydroxide (10 ml) and the resulting solution was left standing at room temperature overnight. The solvent was evaporated in vacuo. The residue was dissolved in water and acidified with 2M hydrochloric acid to pH 4. The resulting precipitate was filtered off, washed with water and dried in vacuo to give the title compound as an orange solid (0.8 g).

Workup

  1. waitthe resulting solution was left
  2. customThe solvent was evaporated in vacuo
  3. dissolutionThe residue was dissolved in water
  4. filtrationThe resulting precipitate was filtered off
  5. washwashed with water
  6. customdried in vacuo

Sources & evidence

ORD record
ord-763d12d6e36a41e6b91f169001a2775a
Source dataset
uspto-grants-2009_07
Patent number
US07566786B2

Reaction notes

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