2-Amino-5-methoxy-7-phenylbenzothiazol → 7-Benzyloxy-4-methoxy-benzothiazole-2-yl-amine

HRID 2308550Notes

Reaction equation

HRID 2308550 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([O:19][CH3:20])=[C:13]([NH:15][C:16]([NH2:18])=[S:17])[CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.COC1C=C(C2C=CC=CC=2)C2SC(N)=NC=2C=1>>[CH2:1]([O:8][C:9]1[C:14]2[S:17][C:16]([NH2:18])=[N:15][C:13]=2[C:12]([O:19][CH3:20])=[CH:11][CH:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 222831342-Amino-5-methoxy-7-phenylbenzothiazolHCID 22283264(5-Benzyloxy-2-methoxy-phenyl)-thiourea

Product 1

HCID 222830597-Benzyloxy-4-methoxy-benzothiazole-2-yl-amineYield 82%

Procedure

Synthesized starting from (5-Benzyloxy-2-methoxy-phenyl)-thiourea in the same manner as described for 5-methoxy-7-phenyl-benzothiazol-2-yl-amine in 82% yield as a beige solid. Mp: 165° C. (dec.).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-52cbc43f584d469096b70abff9f69247
Source dataset
uspto-grants-2004_12
Patent number
US06835732B2

Reaction notes

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