4-Methoxy-6-methyl-1,3,5-triazin-2-ylphenylcarbamate → HCID 20187146, compound

HRID 2308583Notes

Reaction equation

HRID 2308583 reaction equation
[CH3:1][O:2][C:3]1[N:8]=[C:7]([CH3:9])[N:6]=[C:5]([N:10](C2C=CC=CC=2)[C:11](=[O:13])[O-])[N:4]=1.[CH3:20][N:21]([CH3:32])[C:22]1[C:27]([S:28]([NH2:31])(=[O:30])=[O:29])=[CH:26][CH:25]=[CH:24][N:23]=1>O1CCOCC1>[CH3:20][N:21]([CH3:32])[C:22]1[C:27]([S:28]([NH:31][C:11]([NH:10][C:5]2[N:4]=[C:3]([O:2][CH3:1])[N:8]=[C:7]([CH3:9])[N:6]=2)=[O:13])(=[O:30])=[O:29])=[CH:26][CH:25]=[CH:24][N:23]=1

Participants

4

Reactant 2

HCID 199952694-Methoxy-6-methyl-1,3,5-triazin-2-ylphenylcarbamateHCID 20187151HCID 20187151, compound

Product 1

HCID 20187146HCID 20187146, compoundYield 89.6%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

3.28 g of N-(4-methoxy-6-methyl-1,3,5-triazin-2-yl)phenylcarbamate are added at room temperature to a mixture of 2.41 g of 2-dimethylamino-3-pyridylsulfonamide and 1.9 ml of 1,7-diazabicyclo[5.4.0]undec-7-ene in 30 ml of absolute dioxan. The mixture is stirred for 1 hour at this temperature and then concentrated in vacuo. The residue is stirred in 10 ml of 1N aqueous HCl and filtered. The filter residue is washed with water and ether and dried, affording 3.94 g of the title urea with a melting point of 173°-175° C.

Workup

  1. concentrationconcentrated in vacuo
  2. stirringThe residue is stirred in 10 ml of 1N aqueous HCl
  3. filtrationfiltered
  4. washThe filter residue is washed with water and ether
  5. customdried

Sources & evidence

ORD record
ord-7068484b8510417c9538ef571121fe94
Source dataset
uspto-grants-1987_09
Patent number
US04690707

Reaction notes

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