HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2308585Generated: October 25, 2026
Lawesson's reagent → 5-[2'-Chloro-4'-(trifluoromethyl)phenoxy]-2-nitrothiobenzamide
https://huagongshe.com/reaction/2308585
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Lawesson's reagent | HCID 87949 | — |
| Reactant | 5-(2-Chloro-4-trifluoromethylphenoxy)-2-nitrobenzamide | HCID 15335019 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 5-[2'-Chloro-4'-(trifluoromethyl)phenoxy]-2-nitrothiobenzamide | HCID 20187203 | 128.8% |
Reaction Steps
A suspension of 5-[2'-chloro-4'-(trifluoromethyl)phenoxy]-2-nitrobenzamide (54.1 g; 0.15 mol) and 2,4-bis(4-methoxyphenyl)-1,3-dithia-2,4-diphosphetane-2,4-disulphide (LAWESSON's reagent) (28 g; 0.075 mol) in toluene (250 cc) is prepared. It is heated to 100° C., with stirring, and the heating is continued for 1 hour at this temperature. The toluene is removed by evaporation and the residue is purified by chromatography. This gives a yellow solid of 5-[2'-chloro-4'-(trifluoromethyl)phenoxy]-2-nitrothiobenzamide (36.4 g; yield 65%) melting at 152° C. and having the formula: ##STR21##
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04690708 |
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| Source dataset | uspto-grants-1987_09 |
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| ORD ID | ord-40ec2422ccb2469288e4c169f5b396c0 |
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| Source note | uspto-grants-1987_09 |
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