Sodium Hydroxide → HCID 131715239, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 8.5 g of 6-methyl-8β-[N-(2-methoxycarbonyl-ethyl)aminomethyl]-ergoline (II: R1 =R2 =R3 =H, R4 =CH3, n=1, A=CH2 --CHR6, R6 =H, B=COOCH3 ; prepared as described in Example 1) and 2.86 g of potassium cyanate in 120 ml of water and 35 ml of 1N hydrochloric acid was heated at 60° C. for one hour. The solution was then neutralized with 1N sodium hydroxide and extracted with chloroform. The organic layer was evaporated off, and the residue was purified by column chromatography on silica gel, to give 6.5 g of the title compound. Rf in ethyl acetate:dimethylformamide:n-butanol:pyridine (4:3:3:1 by volume)=0.45; MS (F.D.): 384 (M+), 352 (M+ --CH3OH).

Provenance & Evidence