Methyl Isocyanate → HCID 131715240, compound

HRID 2308605Notes

Reaction equation

HRID 2308605 reaction equation
[CH3:1][N:2]1[C@H:16]2[C@@H:6]([C:7]3[CH:8]=[CH:9][CH:10]=[C:11]4[C:17]=3[C:14]([CH2:15]2)=[CH:13][NH:12]4)[CH2:5][C@@H:4]([CH2:18][NH:19][CH2:20][CH2:21][C:22]([O:24][CH3:25])=[O:23])[CH2:3]1.[CH3:26][N:27]=[C:28]=[O:29]>N1C=CC=CC=1>[CH3:1][N:2]1[C@H:16]2[C@@H:6]([C:7]3[CH:8]=[CH:9][CH:10]=[C:11]4[C:17]=3[C:14]([CH2:15]2)=[CH:13][NH:12]4)[CH2:5][C@@H:4]([CH2:18][N:19]([CH2:20][CH2:21][C:22]([O:24][CH3:25])=[O:23])[C:28](=[O:29])[NH:27][CH3:26])[CH2:3]1

Participants

4

Reactant 2

HCID 12228Methyl IsocyanateHCID 70424265HCID 70424265, compound

Product 1

HCID 131715240HCID 131715240, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Conditions

Temperature
60 °C

Procedure

A mixture of 8.5 g of 6-methyl-8β-[N-(2-methoxycarbonylethyl)-aminomethyl]-ergoline (prepared as described in Example 1) and 2.95 ml of methyl isocyanate in 100 ml of pyridine was heated at 60° C. for one hour. After evaporating off the solvent, the residue was crystallized from methanol to give 8.5 of the title compound, m.p. 140°-142° C.

Workup

  1. customAfter evaporating off the solvent
  2. customthe residue was crystallized from methanol

Sources & evidence

ORD record
ord-dc0500478c2349d0bf76dca1441f4f3b
Source dataset
uspto-grants-1987_09
Patent number
US04690929

Reaction notes

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