1-Piperazinecarboxaldehyde → HCID 20150154, compound

HRID 2308618Notes

Reaction equation

HRID 2308618 reaction equation
Cl[C:2]1[N:3]=[C:4]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)[C:5]2[N:11]=[CH:10][N:9]=[C:8]([S:12][CH3:13])[C:6]=2[N:7]=1.[CH:20]([N:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1)=[O:21]>O>[CH:20]([N:22]1[CH2:27][CH2:26][N:25]([C:2]2[N:3]=[C:4]([N:14]3[CH2:19][CH2:18][O:17][CH2:16][CH2:15]3)[C:5]3[N:11]=[CH:10][N:9]=[C:8]([S:12][CH3:13])[C:6]=3[N:7]=2)[CH2:24][CH2:23]1)=[O:21]

Participants

4

Reactant 2

HCID 821911-PiperazinecarboxaldehydeHCID 20150148HCID 20150148, compound

Product 1

HCID 20150154HCID 20150154, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

10.4 gm (0.035 mol) of 2-chloro-8-methylthio-4-morpholino-pyrimido-[5,4-d]-pyrimidine (m.p. 179°-180° C.) were heated with 28.5 gm (0.25 mol) of N-formyl-piperazine at about 100° C. for 30 minutes. The resulting solution was taken up in about 300 ml of water, whereby the reaction product was obtained as yellowish precipitate. The precipitate was suction-filtered off, washed with water and dried at 70° C.

Workup

  1. customwhereby the reaction product was obtained as yellowish precipitate
  2. filtrationThe precipitate was suction-filtered off
  3. washwashed with water
  4. customdried at 70° C.

Sources & evidence

ORD record
ord-9162540bec724b2788b2fe5d92260f72
Source dataset
uspto-grants-1987_09
Patent number
US04690923

Reaction notes

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