Benzylamine → Pyrimido(5,4-d)pyrimidin-4-amine, N-(phenylmethyl)-6-(1-piperazinyl)-8-(4-thiomorpholinyl)-, S-oxide

HRID 2308665Notes

Reaction equation

HRID 2308665 reaction equation
CS[C:3]1[C:8]2[N:9]=[C:10]([N:20]3[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]3)[N:11]=[C:12]([N:13]3[CH2:18][CH2:17][S:16](=[O:19])[CH2:15][CH2:14]3)[C:7]=2[N:6]=[CH:5][N:4]=1.[CH2:26]([NH2:33])[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>>[CH2:26]([NH:33][C:3]1[C:8]2[N:9]=[C:10]([N:20]3[CH2:21][CH2:22][NH:23][CH2:24][CH2:25]3)[N:11]=[C:12]([N:13]3[CH2:14][CH2:15][S:16](=[O:19])[CH2:17][CH2:18]3)[C:7]=2[N:6]=[CH:5][N:4]=1)[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1

Participants

3

Reactant 2

HCID 7504BenzylamineHCID 20150234HCID 20150234, compound

Product 1

HCID 3061031Pyrimido(5,4-d)pyrimidin-4-amine, N-(phenylmethyl)-6-(1-piperazinyl)-8-(4-thiomorpholinyl)-, S-oxide

Procedure

1.9 gm (0.005 mol) of 8-methylthio-4-(1-oxido-thiomorpholino)-2-piperazino-pyrimido-[5,4-d]-pyrimidine (m.p.: 253°-255° C.) were heated with 25 ml of benzylamine for about one hour at 150° C. Subsequently, the excess amine was largely distilled off in vacuo, the residue was taken up in about 150 ml of water, and the solution was adjusted to pH 7 with dilute hydrochloric acid. The precipitated reaction product was suction-filtered off, washed with water and dried.

Workup

  1. distillationSubsequently, the excess amine was largely distilled off in vacuo
  2. customThe precipitated reaction product
  3. filtrationwas suction-filtered off
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-e2db2448744d4459b4e2b99a7da566d9
Source dataset
uspto-grants-1987_09
Patent number
US04690923

Reaction notes

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