1-Piperazinecarboxaldehyde → HCID 12817113, compound

HRID 2308684Notes

Reaction equation

[CH2:1]([NH:8][C:9]1[C:14]2[N:15]=[C:16](Cl)[N:17]=[C:18]([N:19]3[CH2:24][CH2:23][S:22][CH2:21][CH2:20]3)[C:13]=2[N:12]=[CH:11][N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:26]([N:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1)=[O:27]>>[CH2:1]([NH:8][C:9]1[C:14]2[N:15]=[C:16]([N:31]3[CH2:32][CH2:33][N:28]([CH:26]=[O:27])[CH2:29][CH2:30]3)[N:17]=[C:18]([N:19]3[CH2:24][CH2:23][S:22][CH2:21][CH2:20]3)[C:13]=2[N:12]=[CH:11][N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 821911-Piperazinecarboxaldehyde

HCID 12817011HCID 12817011, compound

Product 1

HCID 12817113HCID 12817113, compound

Procedure

This compound was prepared analogous to Example 181 from 8-benzylamino-2-chloro-4-thiomorpholino-pyrimido-[5,4-d]-pyrimidine (m.p.: 94°-96° C. and N-formyl-piperazine.

Sources & evidence

ORD record: ord-ae4eeb5d9e65444cba896876ef6118e6
Source dataset: uspto-grants-1987_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04690923

Reaction notes

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