1-Piperazinecarboxaldehyde → HCID 12817115, compound

HRID 2308685Notes

Reaction equation

Cl[C:2]1[N:3]=[C:4]([N:21]2[CH2:26][CH2:25][S:24](=[O:27])[CH2:23][CH2:22]2)[C:5]2[N:11]=[CH:10][N:9]=[C:8]([NH:12][CH2:13][CH2:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[C:6]=2[N:7]=1.[CH:28]([N:30]1[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]1)=[O:29]>>[CH:28]([N:30]1[CH2:35][CH2:34][N:33]([C:2]2[N:3]=[C:4]([N:21]3[CH2:26][CH2:25][S:24](=[O:27])[CH2:23][CH2:22]3)[C:5]3[N:11]=[CH:10][N:9]=[C:8]([NH:12][CH2:13][CH2:14][C:15]4[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=4)[C:6]=3[N:7]=2)[CH2:32][CH2:31]1)=[O:29]

Participants

Reactant 2

HCID 821911-Piperazinecarboxaldehyde

HCID 12817015HCID 12817015, compound

Product 1

HCID 12817115HCID 12817115, compound

Procedure

This compound was prepared analogous to Example 181 from 2-chloro-4-(1-oxido-thiomorpholino)-8-phenethylamino-pyrimido-[5,4-d]-pyrimidine (m.p.: 198°-200° C.) and N-formyl-piperazine.

Sources & evidence

ORD record: ord-7d56f2b5fa294c49869df8b0b7bcddf0
Source dataset: uspto-grants-1987_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04690923

Reaction notes

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