Sodium Carbonate → HCID 20187486, compound

Participants

Reaction Steps

12.15 g (0.05 mol) of 2-bromo-4'-hydroxy-3'-methylpropiophenone are dissolved in 25 ml of ethanol, 8.75 g (0.05 mol) of 4-benzylpiperidine diluted in 25 ml of ethanol, and then 5.4 g (0.05 mol) of sodium carbonate, are added and the mixture is heated under reflux for 1 and a half hours. The solvent is driven off and the residue is chromatographed on 100 g of silica using acetone as the eluant. This gives 18.4 g of a thick oil, which is used as such.

Provenance & Evidence