Sodium Carbonate → HCID 20187473, compound

HRID 2308758Notes

Reaction equation

HRID 2308758 reaction equation
C(=O)([O-])[O-].[Na+].[Na+].Br[CH:8]([CH3:20])[C:9]([C:11]1[CH:16]=[C:15]([CH3:17])[C:14]([OH:18])=[C:13]([CH3:19])[CH:12]=1)=[O:10].[F:21][C:22]1[CH:34]=[CH:33][C:25]([CH2:26][CH:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)=[CH:24][CH:23]=1>C(O)C>[F:21][C:22]1[CH:23]=[CH:24][C:25]([CH2:26][CH:27]2[CH2:28][CH2:29][N:30]([CH:8]([CH3:20])[C:9]([C:11]3[CH:16]=[C:15]([CH3:17])[C:14]([OH:18])=[C:13]([CH3:19])[CH:12]=3)=[O:10])[CH2:31][CH2:32]2)=[CH:33][CH:34]=1

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 36998414-(4-Fluoro-benzyl)-piperidineHCID 20185248HCID 20185248, compound

Product 1

HCID 20187473HCID 20187473, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2.12 g (0.02 mol) of sodium carbonate are added to a mixture of 5.14 g (0.02 mol) of 2-bromo-4'-hydroxy-3',5'-dimethylpropiophenone and 4 g (0.02 mol) of 4-(4-fluorobenzyl)-piperidine in 25 ml of ethanol and the mixture is heated under reflux for 3 hours. It is left to stand overnight and then purified by chromatography on a column of silica using acetone as the eluant. This give 6.6 g of a brown oil, which is used as such.

Workup

  1. temperaturethe mixture is heated
  2. temperatureunder reflux for 3 hours
  3. waitIt is left
  4. custompurified by chromatography on a column of silica

Sources & evidence

ORD record
ord-e26539f3b56648e097133723181d6409
Source dataset
uspto-grants-1987_09
Patent number
US04690931

Reaction notes

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