1-[4-(Benzyloxy)phenyl]-2-(4-benzylpiperidin-1-yl)propan-1-one → HCID 12613164, compound

HRID 2308762Notes

Reaction equation

HRID 2308762 reaction equation
[CH2:1]([CH:8]1[CH2:13][CH2:12][N:11]([CH:14]([CH3:31])[C:15]([C:17]2[CH:22]=[CH:21][C:20]([O:23]CC3C=CC=CC=3)=[CH:19][CH:18]=2)=[O:16])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(O)C.C(O)(=O)C.[Pd]>[CH2:1]([CH:8]1[CH2:9][CH2:10][N:11]([CH:14]([CH3:31])[C:15]([C:17]2[CH:22]=[CH:21][C:20]([OH:23])=[CH:19][CH:18]=2)=[O:16])[CH2:12][CH2:13]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 1

HCID 30157401-[4-(Benzyloxy)phenyl]-2-(4-benzylpiperidin-1-yl)propan-1-one

Product 1

HCID 12613164HCID 12613164, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolventHCID 702EthanolSolvent

Procedure

25 g of 2-(4-benzylpiperidino)-4'-benzyloxypropiophenone are debenzylated in 200 ml of ethanol and 10 ml of acetic acid, in a Parr apparatus, in the presence of 1 g of 10% palladium-on-charcoal under a pressure of 0.1 MPa for 3 hours. The product obtained is isolated by filtering off the catalyst and evaporating off the solvent.

Workup

  1. customThe product obtained
  2. customis isolated
  3. filtrationby filtering off the catalyst
  4. customevaporating off the solvent

Sources & evidence

ORD record
ord-ad02ccbb874446eba576ae8fdc9ec457
Source dataset
uspto-grants-1987_09
Patent number
US04690931

Reaction notes

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