Pyridine → HCID 13322453, compound

HRID 2308763Notes

Reaction equation

HRID 2308763 reaction equation
[C:1](Cl)(=[O:17])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].N1C=CC=CC=1.[CH2:25]([CH:32]1[CH2:37][CH2:36][N:35]([CH:38]([CH3:48])[C:39]([C:41]2[CH:46]=[CH:45][C:44]([OH:47])=[CH:43][CH:42]=2)=[O:40])[CH2:34][CH2:33]1)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>C(OCC)C>[CH2:25]([CH:32]1[CH2:33][CH2:34][N:35]([CH:38]([CH3:48])[C:39]([C:41]2[CH:46]=[CH:45][C:44]([O:47][C:1](=[O:17])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])=[CH:43][CH:42]=2)=[O:40])[CH2:36][CH2:37]1)[C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1

Participants

5

Reactant 3

HCID 1049PyridineHCID 8206Palmitoyl chlorideHCID 12613164HCID 12613164, compound

Product 1

HCID 13322453HCID 13322453, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

6.5 g of palmitoyl chloride are added to 40 ml of pyridine containing 7 g of 2-(4-benzylpiperidino)-4'-hydroxypropiophenone and the mixture is stirred for 5 hours. It is diluted with 100 ml of diethyl ether and left to stand overnight. The precipitate is then collected by filtration, washed and dried. 11 g of a product which melts at 185°-192° C. with decomposition are thus isolated.

Workup

  1. waitleft
  2. waitto stand overnight
  3. filtrationThe precipitate is then collected by filtration
  4. washwashed
  5. customdried

Sources & evidence

ORD record
ord-51b0e0986eee4828a67721e42d310181
Source dataset
uspto-grants-1987_09
Patent number
US04690931

Reaction notes

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