Diazomethane → HCID 53687305, compound

HRID 2308771Notes

Reaction equation

HRID 2308771 reaction equation
[C:1]([CH2:9][C:10]([N:12]1[CH2:19][CH2:18][CH2:17][C@H:13]1[C:14]([OH:16])=[O:15])=[S:11])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N+](=[CH2:22])=[N-]>CO.C(O)(=O)C>[CH3:22][O:15][C:14](=[O:16])[C@@H:13]1[CH2:17][CH2:18][CH2:19][N:12]1[C:10](=[S:11])[CH2:9][C:1](=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 9550DiazomethaneHCID 53833353HCID 53833353, compound

Product 1

HCID 53687305HCID 53687305, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidCatalystHCID 887MethanolSolvent

Procedure

N-(2-Benzoylthioacetyl)-L-proline obtained in Example 16, is dissolved in methanol and an ethereal solution of diazomethane is added until there is a persistent yellow color. After 15 minutes, a few drops of acetic acid are added and the solvent is removed in vacuo to obtain N-(2-benzoylthioacetyl)-L-proline methyl ester.

Workup

  1. customthe solvent is removed in vacuo

Sources & evidence

ORD record
ord-6c596853cdf04b12afc28277f856fa68
Source dataset
uspto-grants-1987_09
Patent number
US04690936

Reaction notes

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