反应详情

To a mixture of N,O-dimethylhydroxylamine hydrochloride (1.1 g) and pyridine (1.82 mL) in dichloromethane (50 mL) was added 3-phenylpropionyl chloride (1.52 mL) under ice-cooling, and the mixture was stirred at room temperature for 5 hours. The reaction mixture was concentrated under reduced pressure. To the residue was added 1 mol/L hydrochloric acid, and the mixture was extracted with ethyl acetate. The extract was washed with water and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure to give the title compound (1.89 g).

1. temperaturecooling
2. concentrationThe reaction mixture was concentrated under reduced pressure
3. additionTo the residue was added 1 mol/L hydrochloric acid
4. extractionthe mixture was extracted with ethyl acetate
5. washThe extract was washed with water
6. dry with materialdried over anhydrous magnesium sulfate
7. customThe solvent was removed under reduced pressure