HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 1-[3-(Acetylthio)-2-(methoxycarbonylmethyl)propanoyl]-L-proline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | 1-[3-(acetylthio)-2-methoxycarbonylmethylpropanoyl]-L-proline tert-butyl ester | HCID 54504018 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Solvent | Anisole | HCID 7519 | — |
| Product | 1-[3-(Acetylthio)-2-(methoxycarbonylmethyl)propanoyl]-L-proline | HCID 54112383 | — |
Reaction Steps
2.9 g. of the product from Example 80 is dissolved in a mixture of trifluoroacetic acid (17.5 ml.) and anisole (8.4 ml.). After one hour storage at room temperature, the excess trifluoroacetic acid is removed in vacuo and the residue is precipitated twice from ether-hexane to yield 2.1 g. of the named product. Rf : 0.4 (silica gel-benzene:acetic acid, 75.25).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04690936 |
| Source dataset | uspto-grants-1987_09 |
| ORD ID | ord-adaaba07b33f4d71a383c33c39a82cbb |
| Source note | uspto-grants-1987_09 |