Methanol → HCID 13960810, compound

Participants

Reaction Steps

2,6-Bis(N-methylcarbamoyl)pyridine-4-carboxylic acid (1 g) was mixed with methanol (50 ml), and to the mixture was added thionyl chloride (2 ml). After addition of thionyl chloride, the mixture was stirred at room temperature overnight. The mixture was then evaporated under reduced pressure, and water was added to the residue followed by extraction with chloroform. The organic layer was washed with a saturated sodium bicarbonate aqueous solution, and evaporated to dryness. The residual crystals were recrystallized from toluene to give 0.4 g of methyl 2,6-bis(N-methylcarbamoyl)pyridine-4-carboxylate. m.p. 202°-203° C.

Provenance & Evidence