Tetrahydrofuran → HCID 13960815, compound

Participants

Reaction Steps

2,6-Bis(N-methylcarbamoyl)pyridine-4-carboxylic acid (2.3 g) prepared in Example 2 was mixed with 50 ml of tetrahydrofuran and 3.1 g of ethylene glycol. After addition of 2.5 g of dicyclohexyl carbodiimide, the mixture was stirred at room temperature overnight. The mixture was then evaporated and the residue was purified by a column chromatography on silica gel, and recrystallized from dimethylformamide/benzene to give 0.3 g of 2-hydroxyethyl 2,6-bis(N-methylcarbamoyl)pyridine-4-carboxylate. m.p. 214°-215° C.

Provenance & Evidence