反应详情

To a mixture of 2.50 g 2-(4-(1-methylethenyl)phenoxy)ethanol, 10 ml methanol, and 1.1 equivalents 50% aqueous H2O2 were added 0.1 equivalent 98% H2SO4. The reaction mixture warmed itself to reflux which subsided in a few minutes. After addition of 0.2 equivalent Na2SO3, methanol was removed under reduced pressure. The residue was taken up in ether, dried over Na2SO4 and NaHCO3, and filtered. Removal of solvent left 4-(2-hydroxyethoxy)phenol in quantitative yield.

1. temperatureThe reaction mixture warmed itself
2. temperatureto reflux which
3. waitsubsided in a few minutes
4. customwas removed under reduced pressure
5. dry with materialdried over Na2SO4 and NaHCO3
6. filtrationfiltered
7. customRemoval of solvent
8. waitleft 4-(2-hydroxyethoxy)phenol in quantitative yield