Sodium Hydroxide → HCID 20186440, compound

Participants

Reaction Steps

A mixture of 8-chloro-2-ethoxycarbonylmethyl-2,4-dihydro[1]benzothiopyrano[4,3-c]pyrazole 5-oxide (3 g) and 1N aqueous sodium hydroxide (9.25 ml) in methanol (90 ml) was stirred at ambient temperature for 30 minutes and then evaporated in vacuo. To the residue were added 1N hydrochloric acid and ethyl acetate, the insoluble material was collected by suction, and washed with water. The obtained crude product was recrystallized from a mixture of ethanol and n-hexane to give 2-carboxymethyl-8-chloro-2,4-dihydro[1]benzothiopyrano[4,3-c]pyrazole 5-oxide (0.78 g).

Provenance & Evidence