Hydrazine hydrate (1:1) → Brn 6572492

Participants

Reaction Steps

A solution of dl-6-acetylamino-1-oxo-1,2,3,4-tetrahydro-naphth-2-yl-acetic acid (3.27 g) in ethanol (60 ml) was treated with 90% hydrazine hydrate (1 ml) and heated at the reflux temperature for 3 hrs. After cooling at 0°-5° C., the precipitate is separated by filtration and recrystallized from acetone-ethanol to yield 8-acetylamino-4,4a,5,6-tetrahydro-2H-benzo(h)-cinnolin-3-one m.p. 284° C.

Provenance & Evidence