3,4-Diaminopyridine → HCID 178420848, compound

HRID 2308956Notes

Reaction equation

HRID 2308956 reaction equation
[NH2:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[NH2:8].[S:9]1[CH:13]=[CH:12][CH:11]=[C:10]1[C:14](O)=O>>[S:9]1[CH:13]=[CH:12][CH:11]=[C:10]1[C:14]1[NH:8][C:7]2[CH:6]=[CH:5][N:4]=[CH:3][C:2]=2[N:1]=1

Participants

3

Reactant 2

HCID 59183,4-DiaminopyridineHCID 107002-Thiophenecarboxylic acid

Product 1

HCID 178420848HCID 178420848, compoundYield 24.6%

Conditions

Temperature
160 °C

Procedure

A mixture of 1.1 g (10 mM) of 3,4-diaminopyridine, 1.3 g (10 mM) of thiophene-2-carboxylic acid, and 50 g of polyphosphoric acid was heated at 160° C. for four hours. The reaction mixture was added to 100 g of ice and stirred for fifteen minutes. The precipitated solid was collected by filtration and dried to give 500 mg of 2-(2-thienyl)-1H-imidazolo[4,5-c]pyridine; mp 265°-268° C.

Workup

  1. filtrationThe precipitated solid was collected by filtration
  2. customdried

Sources & evidence

ORD record
ord-cc07e242229b4b7ab9178b5998a03911
Source dataset
uspto-grants-1987_09
Patent number
US04692443

Reaction notes

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