Sodium Iodide → HCID 54238241, compound

Participants

Reaction Steps

1 g of 4-hydroxy-4'-nitrobenzophenone was added to 8 ml of DMF containing 110 mg of NaH. The mixture was heated at 40°-50° C. for 30 minutes, then treated with 1.29 g of (R)-3-tosyloxy-1,2-propanediol acetonide and a trace of NaI and heated at 150° C. (oil-bath) under argon for 4 hours. After working-up and purification there were obtained 930 mg (64% ) of 4-[[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy]-4'-nitrobenzophenone, m.p. 92°-93° C., [α]D20 +5.3° (c 1%, MeOH).

Provenance & Evidence