Methyl 2-(4-(2-oxopropyl)phenoxy)acetate → HCID 20186757, compound

HRID 2309007Notes

Reaction equation

HRID 2309007 reaction equation
[C:1]([CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][C:14](=O)[CH3:15])=[CH:9][CH:8]=1)([O:3][CH3:4])=[O:2].[OH:17][CH2:18][CH2:19][CH2:20][O:21][CH:22]([C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([Cl:31])[CH:26]=1)[CH2:23][NH2:24]>C(OCC)(=O)C.C1CCCCC1>[ClH:31].[C:1]([CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH:14]([NH:24][CH2:23][CH:22]([O:21][CH2:20][CH2:19][CH2:18][OH:17])[C:25]2[CH:30]=[CH:29][CH:28]=[C:27]([Cl:31])[CH:26]=2)[CH3:15])=[CH:9][CH:8]=1)([O:3][CH3:4])=[O:2]

Participants

4

Reactant 2

HCID 13851156Methyl 2-(4-(2-oxopropyl)phenoxy)acetateHCID 20186759HCID 20186759, compound

Product 1

HCID 20186757HCID 20186757, compound

Reagents, catalysts & solvents 1

HCID 21867204Cyclohexane ethylacetateSolvent

Procedure

The title compound was prepared as a 56:44 mixture of diastereoisomers, mp 110°-114° C. (ethyl acetate-cyclohexane), from 1-(4-carbomethoxymethoxyphenyl)propan-2-one (4.3 g) and 2-(3-hydroxypropoxy)-2-(3-chlorophenyl)ethanamine (4.5 g) by an analogous procedure to that described in Example 1.

Sources & evidence

ORD record
ord-c183761b30d144ac9a33b9235364f55f
Source dataset
uspto-grants-1987_09
Patent number
US04692465

Reaction notes

Loading…