N-(3-acetylthio-2-trifluoromethylpropanoyl)-L-proline tertbutyl ester → 1-(3-acetylthio-2-trifluoromethylpropanoyl)-L-proline

Participants

Reaction Steps

N-(3-Acetylthio-2-trifluoromethylpropanoyl)-L-proline tert-butyl ester (8 g.) is dissolved in a mixture of anisole (55 ml.) and trifluoroacetic acid (110 ml.). After one hour storage at room temperature the solvent is removed in vacuo and the residue is precipitated several times for ether-hexane to give N-(3-acetylthio-2-trifluoromethylpropanoyl)-L-proline.

Provenance & Evidence