Methanol → HCID 20498189, compound

Participants

Reaction Steps

The 5-(2-furyl)-hydantoin from Step A (22.0 g, 0.133 mol) and barium hydroxide octahydrate (67.3 g, 0.213 mol) were added to 325 ml of boiling water. The mixture was refluxed for 24 hrs., cooled to room temperature, and then the barium carbonate was filtered off. The filtrate was treated again with ammonium carbonate (12.8 g, 0.133 mol) to precipitate the barium remaining in solution. The resulting mixture was refluxed for 5 minutes and filtered. The filtrate was evaporated to dryness. The remaining brown crystals were recrystallized from a 1:2 mixture of water:methanol to give 9.7 g (52% yield) of 2-furylglycine as light beige crystals: mp 195°-199° C.

Provenance & Evidence