反应详情

3 equivalents of ozone are conveyed through a solution, cooled to -30°, of 8.4 g of 2-[(3S,4R)-4-acetylthio-3-methoxy-2-oxoazetidin-1-yl]-3-methylcrotonic acid 2,2,2-trichloroethyl ester in 765 ml of methyl acetate. After treating with ozone, the reaction mixture is left to stand at the same temperature for 15 minutes and then the excess ozone is removed by a nitrogen current. The reaction mixture is washed at 0° with a 10% aqueous sodium bisulphite solution and then with sodium chloride solution. After separating off, the combined aqueous phases are extracted a further 4 times with methyl acetate. The combined methyl ester solutions are dried over sodium sulphate and concentrated by evaporation in vacuo.

1. waitthe reaction mixture is left
2. customthe excess ozone is removed by a nitrogen current
3. washThe reaction mixture is washed at 0° with a 10% aqueous sodium bisulphite solution
4. customAfter separating off
5. extractionthe combined aqueous phases are extracted a further 4 times with methyl acetate
6. dry with materialThe combined methyl ester solutions are dried over sodium sulphate
7. concentrationconcentrated by evaporation in vacuo