HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Iodide → (3S,4R)-4-(4-p-nitrobenzyloxycarbonylaminobutyrylthio)-3-methoxy-2-oxoazetidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | (3S,4R)-4-chloro-3-methoxy-2-oxoazetidine | HCID 55300418 | — |
| Reactant | HCID 178523351 | HCID 178523351 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Phosphate | HCID 1061 | — |
| Product | (3S,4R)-4-(4-p-nitrobenzyloxycarbonylaminobutyrylthio)-3-methoxy-2-oxoazetidine | HCID 18609679 | — |
Reaction Steps
A solution of 350 mg of 4-p-nitrobenzyloxycarbonylaminothiobutyric acid sodium salt in 4 ml of water is added dropwise to a solution of 135 mg of (3S,4R)-4-chloro-3-methoxy-2-oxoazetidine in 6 ml of a phosphate buffer of a pH of 7 and 0.4 ml of dioxan in the presence of 150 mg of sodium iodide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04692442 |
| Source dataset | uspto-grants-1987_09 |
| ORD ID | ord-9448a214c06e44d9b56f59b6a6f5b32d |
| Source note | uspto-grants-1987_09 |