Dicyclohexylcarbodiimide → HCID 20186850, compound

HRID 2309135Notes

Reaction equation

[C:1]([O:5][C:6]([CH2:8][N:9]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH2:13][CH:12]([NH2:20])[C:10]1=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:21][N:22]([CH3:32])[C:23]1[CH:31]=[CH:30][C:26]([C:27](O)=[O:28])=[CH:25][CH:24]=1.ON1C2C=CC=CC=2N=N1.C1(N=C=NC2CCCCC2)CCCCC1>>[C:1]([O:5][C:6]([CH2:8][N:9]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH2:13][CH:12]([NH:20][C:27](=[O:28])[C:26]2[CH:25]=[CH:24][C:23]([N:22]([CH3:21])[CH3:32])=[CH:31][CH:30]=2)[C:10]1=[O:11])=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

Reactant 4

HCID 10868Dicyclohexylcarbodiimide

HCID 120924-(Dimethylamino)benzoic acid

HCID 757711-Hydroxybenzotriazole

HCID 14590305HCID 14590305, compound2×

Product 1

HCID 20186850HCID 20186850, compoundYield 43.5%

Procedure

The title compound (0.2 gm) was prepared from 0.3 gm of 1-t-butoxycarbonylmethyl-3-aminohomodihydrocarbostyril (Example 2, Compound B), 0.19 gm of 4-dimethylaminobenzoic acid, 0.15 gm of 1-hydroxybenzotriazole and 0.23 gm of dicyclohexylcarbodiimide by a procedure analogous to the one employed in Example 10.

Sources & evidence

ORD record: ord-39f746eb24124fcc885150639d1747fc
Source dataset: uspto-grants-1987_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04692522

Reaction notes

Loading…