HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → Ethyl 5-(chloromethyl)-1,3-dimethyl-1H-pyrazole-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-Ethoxycarbonyl-5-(1-hydroxymethyl)-1,3-dimethylpyrazole | HCID 12520024 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Ethyl 5-(chloromethyl)-1,3-dimethyl-1H-pyrazole-4-carboxylate | HCID 13729351 | — |
Reaction Steps
This material was combined with the product of a second reaction (5.0 g of 4-ethoxycarbonyl-5-(1-hydroxymethyl)-1,3-dimethylpyrazole and 1.93 ml thionyl chloride), dissolved in dichloromethane, washed with brine, dried (MgSO4) and concentrated to give 10.7 g of a solid, mp. 81°-83° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04693743 |
| Source dataset | uspto-grants-1987_09 |
| ORD ID | ord-87970a4b5e984052a08bdfdc1600ad8e |
| Source note | uspto-grants-1987_09 |