Dimethylformamide → 2-Amino-4-methyl-6-(1,1,2-trifluoro-2-chloro-ethoxy)-pyrimidine

Participants

Reaction Steps

25 g of 2 -amino-4-hydroxy-6-methyl-pyrimidine, 25.6 g of chlorotrifluoroethylene, 13.8 of potassium hydroxide and 200 ml of dimethylformamide are stirred together at 60° in an autoclave for 8 hours. The mixture is diluted with water and extracted with ethyl acetate and the extract is evaporated to give a dark oil. A little methylene chloride is added and the crystalline precipitate formed is separated off to give 8.7 g of 2-amino-4-methyl-6-(1,1,2,-trifluoro-2-chloro-ethoxy)-pyrimidine of melting point 73°-74° C.

Provenance & Evidence