HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → Boc-Gly-Phe-Gly-Val-Gly-Ala-Gly-Val-Pro-OBzl
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Edci hobt | HCID 18410139 | — |
| Reactant | Boc-Gly-Phe-Gly-Val-Gly-OH | HCID 131715252 | — |
| Reactant | Boc-Ala-Gly-Val-Pro-OBzl | HCID 131715254 | — |
| Reactant | Boc-Val-Pro-Gly-Phe-Gly-Val-Gly-OBzl | HCID 131715255 | — |
| Product | Boc-Gly-Phe-Gly-Val-Gly-Ala-Gly-Val-Pro-OBzl | HCID 131715253 | 75.5% |
Reaction Steps
After deblocking XIII with TFA, the salt was coupled with XIV using EDCI/HOBt and worked up as for the preparation VI. The title compound was obtained in 75.5% yield. Rf2 0.57. Anal. calcd. for C47H67N9O12 ·2H2O: C 57.06, H 7.23, N 12.74%. Found C 54.23, H 7.10, N 12.74%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04693718 |
| Source dataset | uspto-grants-1987_09 |
| ORD ID | ord-2ecb7092c9954ebca9e98a301da66407 |
| Source note | uspto-grants-1987_09 |