Hydrochloric Acid → HCID 14214145, compound

Participants

Reaction Steps

330 mg (0.8 mM) of (II), dissolved in 30 ml of glacial acetic acid, are hydrogenated for 4 hours, in the presence of 330 mg of Pd (5%) on charcoal and of 1 ml (1 mM) of N HCl. It is checked, by thin layer chromatography on silica gel in the system ethyl acetate-pyridine-acetic acid-water (6:2:0.6:1), that the hydrogenation is complete, then the catalyst is filtered off and the solvent concentrated. The residual oil is dried carefully under vacuum (dessicator, with P2O5) and used as such in the following step.

Provenance & Evidence