HCID 14221783, compound → HCID 20186013, compound

HRID 2309194Notes

Reaction equation

HRID 2309194 reaction equation
[N:1]1([CH2:7][C:8]2[CH:9]=[C:10]([CH:15]=[CH:16][CH:17]=2)[O:11][CH2:12][CH2:13][NH2:14])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[N+](N[C:22]1[NH:27][C:26](=[O:28])[C:25]([O:29][CH3:30])=[CH:24][N:23]=1)([O-])=O>N1C=CC=CC=1>[N:1]1([CH2:7][C:8]2[CH:9]=[C:10]([CH:15]=[CH:16][CH:17]=2)[O:11][CH2:12][CH2:13][NH:14][C:22]2[NH:27][C:26](=[O:28])[C:25]([O:29][CH3:30])=[CH:24][N:23]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 14221783HCID 14221783, compoundHCID 20186014HCID 20186014, compound

Product 1

HCID 20186013HCID 20186013, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

2-[3-(Piperidinomethyl)phenoxy]ethylamine * (1.38 g) and 2-nitroamino-5-methoxypyrimidin-4-one(1.00 g) were stirred under reflux, for 19 hours, in pyridine (15 ml). The reaction mixture was worked-up in a manner analogous to that of Example 5 to give the title compound which was converted to 2-[2-[3-(piperidinomethyl)phenoxy]-ethylamino]-5-methoxypyrimidin-4-one maleate.

Sources & evidence

ORD record
ord-0fa9604fdc8d476395242b49850f9ab0
Source dataset
uspto-grants-1987_09
Patent number
US04694008

Reaction notes

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