Triethyl phosphite → Ethyl 2-(diethoxyphosphinyl)pentanoate

HRID 2309204Notes

Reaction equation

Br[CH:2]([CH2:8][CH2:9][CH3:10])[C:3]([O:5][CH2:6][CH3:7])=[O:4].[CH2:11]([O:13][P:14]([O:18]CC)[O:15][CH2:16][CH3:17])[CH3:12]>>[CH3:10][CH2:9][CH2:8][CH:2]([P:14]([O:15][CH2:16][CH3:17])([O:13][CH2:11][CH3:12])=[O:18])[C:3]([O:5][CH2:6][CH3:7])=[O:4]

Participants

Reactant 2

HCID 31215Triethyl phosphite

HCID 79071Ethyl 2-bromovalerate

Product 1

HCID 98244Ethyl 2-(diethoxyphosphinyl)pentanoate

Procedure

In analogy to the procedure given in Example 3: Ethyl 2-bromovalerate was treated with triethylphosphite to give triethyl 2-phosphonovalerate as a colorless clear liquid, b.p.=95°-110° C. (0.175 mm of Hg).

Sources & evidence

ORD record: ord-5a8212c1128b4f349548330a4a8b18ab
Source dataset: uspto-grants-1987_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04694023

Reaction notes

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