Hydrochloric Acid → 2-Amino-3-(2-oxoindolin-3-yl)propanoic acid hydrochloride

Participants

Reaction Steps

10.2 Grams of L-tryptophane was suspended in 7.8 g of dimethyl sulfoxide, then 16.6 ml of concentrated hydrochloric acid was added all at once in the suspension, and the mixture was stirred at a room temperature overnight. The crystals formed in the reaction mixture were collected by filtration, then washed with acetone and dried to obtain 9.8 g of 2-amino-3-(oxindol-3-yl)propionic acid hydrochloride. [α]D20 +22.5° (C=1, methanol)

Provenance & Evidence