HCID 13393250, compound → HCID 20186084, compound

Participants

Reaction Steps

To 114 g of 3-(2,2-diethoxyethyl)-1-methyloxindole was added 110 ml of 5% hydrochloric acid aqueous solution, and the mixture was stirred at a room temperature for 3 hours. The reaction mixture was filtered and the filtrate was neutralized with sodium carbonate, then extracted with chloroform. The chloroform layer was washed with a saturated sodium chloride aqueous solution, then dried with anhydrous sodium sulfate. The solvent was removed by evaporation to obtain 89 g of 3-formylmethyl-1-methyloxindole.

Provenance & Evidence