Water → HCID 20186091, compound

Participants

Reaction Steps

479 Milligrams of 2-(4-chlorobenzoylamino)-3-(oxindol-3-yl)propionic acid 1/4-hydrate prepared in Example 3 and 70 mg of 50% sodium hydride (in oil) were admixed in 5 ml of dimethylformamide, and the mixture was stirred at a room temperature for 1 hour. Then a mixture containing of 0.17 ml of benzyl chloride in 3 ml of dimethylformamide was added dropwise slowly into the reaction mixture, and the whole reaction mixture was stirred at a room temperature for 4 hours. The reaction mixture was poured into a large volume of water, and the organic material was extracted with chloroform, then the chloroform layer was dried and chloroform was removed by evaporation. There was obtained 110 mg of 2-(4-chlorobenzoylamino)-3-(1-benzyloxindol-3-yl)propionic acid.

Provenance & Evidence