HCID 13393252, compound → HCID 13606280, compound

Participants

Reaction Steps

2 Grams of 3-(1-methyloxindol-3-yl)-2-aminopropionic acid prepared in Reference Example 5 was suspended in 50 ml of 1-methyl-2-pyrrolidone, then 2.2 g of 3-(4-chlorobenzoyl)benzoxazolin-2-thione was added thereto, and the reaction mixture was stirred at a room temperature for 3 days. The reaction mixture was poured into an ice-water, and the crystals formed were collected by filtration, then the crystals were dissolved in 1N-sodium hydroxide aqueous solution, then the resulting solution was acidified by using 10%-hydrochloric acid, and the crystals formed were collected by filtration. The crystals were dried, washed with chloroform, there was obtained 1.1 g of 2-(4-chlorobenzoylamino)-3-(1-methyloxindol-3-yl)propionic acid. White powdery substance. Melting point: 115°-120° C.

Provenance & Evidence