Methyl iodide → HCID 13559601, compound

Participants

Reaction Steps

2.4 Grams of methyl 2-(4-chlorobenzoylamino)-3-(oxindol-3-yl)propionate prepared in Example 57 was dissolved in 30 ml of acetone and 10 ml of water, then 0.34 g of sodium carbonate and 1 g of methyl iodide were added thereto and the reaction mixture was refluxed for 6 hours. Acetone was removed by evaporation, and the residue was extracted with chloroform, the chloroform layer was washed with water, dried with anhydrous magnesium sulfate, then the solvent was removed by evaporation. The residue was purified by means of a silica gel column chromatography (euting agent: chloroform/methanol=100/1) then recrystallized from hexane-ethyl acetate to obtain 0.5 g of methyl 2-(4-chlorobenzoylamino)-3-(3-methyloxindol-3-yl)propionate in the form of colorless needel-like crystals. Melting point: 201°-202° C.

Provenance & Evidence